By inspection of the data, it could be concluded that
niosomal formulations prepared using Tween 60 yielded a
lower rate of release compared to Tween 80 niosomes which in turn showed lower release than niosomes formulated with
Brij 35. This can be explained by the fact that niosomes
exhibit an alkyl chain length-dependent release and the
higher the chain length, the lower the release rate (26). By
reviewing the data in Table II, Q8h for the niosomal
formulations can be arranged in the following decreasing
order: F10 > F9 > F11 > F12 > F8 > F7 > F5 > F6 > F2 > F1 >
F3 > F4 niosomal vesicles