Vlaev S. et al. considers the possibility to control the depressive symptoms in 5 patients with psychogenic and periodic depression, parallel with the treatment of the pathologically fixed wish to smoke. Tabex was applied in gradually increasing doses, the maximum daily dose being 15 mg (5 tablets 3 times daily). The author has observed a rapid reduction of the depressive symptoms, the improvement of the patients with reactive depression being obtained at the end of the first week, in the patients with periodic depression - by the end of the second week. The improvement is particularly good with respect to the patients' activity, followed by the mood and finally by the depressive mental symptoms. As a side effect, the slight internal tension and a slight decrease of blood pressure are pointed out. The antidepressive action of the drug is explained with the increase of the catecholamine level, especially that of adrenaline, which is reduced in depressive patients. The adrenostimulating effect of Tabex has been well known for a long time, but its antidepressive activity is reported by Antonov L. and V. Velkov in an experiment on laboratory rats (by overcoming Persolt's test of immobility).