Knowledge gaps and future direction
TB remains a major cause of death and morbidity worldwide,
and control efforts so far have not been adequately
administered to limit the epidemic in many parts of the world,
especially in the countries of sub-Saharan Africa and parts of
Eastern Europe. Absence of a cheap point of care diagnostic
test, the long duration of treatment, lack of an effective
vaccine, emergence of drug-resistant tuberculosis, and weak
health systems in resource-poor developing countries are all
factors that continue to hamper progress towards achieving
control of TB worldwide. Understanding of the pathogenesis
of TB disease is also lacking.
Despite this, there isrisingmomentumin basic and applied
research activity that isstarting to yield new diagnostic, treatment,
and prevention methods, and now provide grounds for
optimism. For the first time in more than 40 years, two new
drugs were recently approved by regulatory authoritiesforthe
treatment of MDR-TB. In December 2012, the US Food and
Knowledge gaps and future directionTB remains a major cause of death and morbidity worldwide,and control efforts so far have not been adequatelyadministered to limit the epidemic in many parts of the world,especially in the countries of sub-Saharan Africa and parts ofEastern Europe. Absence of a cheap point of care diagnostictest, the long duration of treatment, lack of an effectivevaccine, emergence of drug-resistant tuberculosis, and weakhealth systems in resource-poor developing countries are allfactors that continue to hamper progress towards achievingcontrol of TB worldwide. Understanding of the pathogenesisof TB disease is also lacking.Despite this, there isrisingmomentumin basic and appliedresearch activity that isstarting to yield new diagnostic, treatment,and prevention methods, and now provide grounds foroptimism. For the first time in more than 40 years, two newdrugs were recently approved by regulatory authoritiesforthetreatment of MDR-TB. In December 2012, the US Food and
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