mmol per liter) at baseline had levels of 126 mg
per deciliter or more at eight weeks, as compared
with 4 of 25 patients in the placebo group (P = 0.73).
There was no difference in the duration of previous
treatment with clozapine between the patients
whose blood glucose increased to at least 126 mg
per deciliter and those whose blood glucose did
not. The levels of total cholesterol, triglycerides,
LDL cholesterol, and HDL cholesterol did not differ
significantly between the two groups at baseline
or at eight weeks, and there were no significant
differences between the two groups in the
changes in these measurements between baseline
and eight weeks. The total white-cell and neutrophil
counts did not differ between the two groups.
There were no statistically significant differences
between the two groups in the incidence of any
side effect (Table 4).