Terms THE PURPOSE OF MECHANICAL VENTILATION IS TO REST THE RESPIRATORY muscles while providing adequate gas, exchange. Ventilatory support proved to be indispensable during the 1952 polio epidemic, in Copenhagen decreasing mortality among. Patients with paralytic polio from more than 80% to approximately 40%. Despite the clear benefits of, this therapy many. Patients eventually die after the initiation of, mechanical ventilation even though their arterial blood gases have normalized. . This mortality as been ascribed to, multiple factors including complications of ventilatign such barotrauma (ie leaks),. Oxygen toxicity and hemodynamic compromise.During the, polio epidemic investigators noted that mechanical ventilation could. Cause structural damage to the lung. In 1967 the term, respirator lung "was coined to describe the diffuse alveolar infifiates. And hyaline membranes that were found on postmortem examination of patients who had undergone mechanical ventilation. More. Recently there has, been a renewed focus on the worsening injury that mechanical ventilation can cause in previously damaged. Lungs and the damage it can initiate in normal lungs. This damage is characterized pathologically by inflammatory, cell infiltrates. Hyaline membranes increased permeability and, vascular, pulmonary edema. The constellation of pulmonary consequences of. Mechanical ventilation has been termed ventilator-induced lung injury. The concept of ventilator-induced lung injury is. Not new. In 1744 John Fothergill, discussed a case of a patient who was "dead in appearance" after exposure to coal fumes. And who was successfully treated by mouth-to-mouth resuscitation. Fothergill noted that mouth-to-mouth resuscitation was. Preferable to using bellows because "the lungs of one man, may bear without injury as great, a force as those of another. Man can exert; which by the bellows cannot always be determin 'd. "Fothergill clearly understood the concept that mechanical. Forces generated by bellows (I E. A ventilator) could lead to injury. However it was, not until early in this century that. The clinical importance of ventilator induced lung injury in adults was confirmed by a study showing that a ventilator strategy. Designed to minimize such injury decreased mortality among patients with the acute respiratory distress syndrome (ARDS). Given the clinical importance of ventilator induced lung injury this article, will review mechanism underlying, the condition. It 's biologic and physiological consequences and clinical, strategies to prevent it and mitigate it' s effects.
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