Renal & hepatic impairment; correct hypovolaemia or Na depletion prior to administration. Severe CHF or underlying renal disease including renal artery stenosis. Renovascular HTN, recent kidney transplantation. Monitor serum K & creatinine. Aortic or mitral valve stenosis; obstructive hypertrophic cardiomyopathy. Primary aldosteronism. Ischaemic heart or cerebrovascular disease. May impair ability to drive or operate machinery. Childn & adolescent