Methods.—We searched MEDLINE,EMBASE, CINAHL, Cochrane database, and international clinical trial registers for
randomized controlled trials comparing parenteral phenothiazines with placebo or another active parenteral agent for treatment
of acute migraine in adults. The primary outcome was relief of headache, and secondary outcome was clinical success.
Analysis was for phenothiazines vs placebo, pooled other active agents, and metoclopramide for each outcome. Odds ratios
(ORs) were calculated and pooled by using a random effects model (RevMan v5).