The results of this study show that cholesterol content,
type of surfactant and the presence of charge inducer dicetyl
phosphate (DCP), altered the entrapment efficiency %EE
and release rate from gentamicin sulphate niosomes. Higher
%EE was obtained with niosomes prepared from Tween 60,
cholesterol and DCP in a 1:1:0.1 molar ratio. The in-vitro
evaluation of gentamicin niosomes in comparison to gentamicin
solution showed that gentamicin niosomes composed of
Tween 60, cholesterol and DCP were the most effective in the
prolongation of drug release from the ocular delivery system.
No signs of irritation was observed upon the application of
the niosome-encapsulated gentamicin to the eyes of albino
rabbits. Niosomes may be considered as promising ophthalmic
carriers for the topical application of gentamicin sulphate