If you have bind the TCP profile to CR VIP it will be applicable between client and Netscaler as Netsacler is in Endpoint mode. The TCP profile settings won’t be applicable in the backend communication i.e from Netscaler to backend server as there is no LB service were we can bind the TCP profile. Also if you would have bound the TCP profile to LB VIP (i.e vip_forward) it’s down so it’s not going to work here as well. So we have to apply the TCP changes on the global parameters