Discussion
In this randomized , controlled trial of the treatment of acute bronchiolitis in infants , we found an unexpected synergism between epinephrine and dexamethasone. Combined therapy with epinephrine and dexamethasone as compared with placebo, appeared to reduce the rate of hospital. admission in the 7 days after study enrollment by 9 percentage points, with a relative risk reduction of 35% these results were not modified by RSV status, status presence or absence of a history of atopy. or the severity or the duration of illness. The effects of combining epinephrine and dexamethasone were most apparent in the first 3 days after study enrollment. We also found an apparent benefit from combined Therapy on our secondary outcomes. Infants in this group were discharged early from medical care and resumed Care and resumed get breathing and normal feeding sooner than did those in The Placebo group-In contrast, neither, neither dexamethasone alone norepinephrine alone had any effect on These outcomes.