Study Design.—We undertook a systematic review
and meta-analysis to determine the efficacy of
parenteral phenothiazines compared with placebo
and to other parenterally administered active agents
for the treatment of acute migraine.
We searched MEDLINE, EMBASE, CINAHL,
the Cochrane database, and international clinical trial
registers for randomized controlled trials comparing
parenteral phenothiazines with placebo or another
active parenteral agent for the treatment of acute
migraine in adults from earliest indexing until
December 31, 2008.We used the terms “migraine” or
“headache” and “phenothiazine” or “chlorpromazine”
or “prochlorperazine” and limited to outputs
to therapeutics and clinical trials. In addition, we
searched for similar systematic reviews and metaanalyses
and used the PubMed “related articles”
feature for all identified trials. Where studies were
recorded as “completed” on clinical trials registers
but not yet published, we attempted to contact the
chief investigators to obtain data.
Studies were selected for inclusion if they were
randomized controlled trials of a parenterally
administered phenothiazine (chlorpromazine,
prochlorperazine, and methotrimeprazine) vs either
placebo or an active parenterally administered comparator
for the treatment of acute migraine. Studies
Study Design.—We undertook a systematic review
and meta-analysis to determine the efficacy of
parenteral phenothiazines compared with placebo
and to other parenterally administered active agents
for the treatment of acute migraine.
We searched MEDLINE, EMBASE, CINAHL,
the Cochrane database, and international clinical trial
registers for randomized controlled trials comparing
parenteral phenothiazines with placebo or another
active parenteral agent for the treatment of acute
migraine in adults from earliest indexing until
December 31, 2008.We used the terms “migraine” or
“headache” and “phenothiazine” or “chlorpromazine”
or “prochlorperazine” and limited to outputs
to therapeutics and clinical trials. In addition, we
searched for similar systematic reviews and metaanalyses
and used the PubMed “related articles”
feature for all identified trials. Where studies were
recorded as “completed” on clinical trials registers
but not yet published, we attempted to contact the
chief investigators to obtain data.
Studies were selected for inclusion if they were
randomized controlled trials of a parenterally
administered phenothiazine (chlorpromazine,
prochlorperazine, and methotrimeprazine) vs either
placebo or an active parenterally administered comparator
for the treatment of acute migraine. Studies
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