In the carrageenan-induced hind paw edema test the obtained data was evaluated by a one-way analysis of variance(one-wayANOVA) followed by Bonferroni’s multiple comparison test. In the analgesic activity test, data was evaluated by a one-way analysis of variance (one-way ANOVA), followed by Tukey’s test. In zinc concentration t-test was employed. P < 0.05 was considered significant.