The photomicrographs (×40) of gentamicin sulphate
niosomes F4 composed of Tween 60, cholesterol and DCP
in a 1:1:0.1 molar ratio and F6 composed of Tween 80 and
cholesterol in a 1:1 molar ratio are shown in Fig. 1a, b,
respectively. We can observe the spherical morphology of the
niosomal preparation F4 and F6. It is also clear that the F4
vesicles are larger in size than those of F6, which is coherent
to the entrapment efficiency results.
Negative stain transmission electron micrographs of
gentamicin F4 and F6 are shown in Fig. 2a, b, respectively.
It is demonstrated that the vesicles are well identified and
present in a nearly perfect sphere-like shape having a large
internal aqueous space.