The data were analysed statistically using one-wayanalysis of variance followed by Duncan's MultipleComparison test. Values of P<0.05 were consideredsignificant.The aqueous extract of Zingiber zerumbet (Group1, 2 and 3) elicited dose-dependent antiinflammatoryactivity (Table 1). At 25 mg/kg concentration,the water extract, had no antiinflammatory property.At 50 and 100 mg/kg the antiinflammatory activitywas 22.6 % and 46.8 % respectively, which weresignificantly different from the control (p<0.05). Theantiinflammatory activities of mefenamic acid (Group8), used as a standard reference drug, was foundto be statistically significant (Table 1). Generally, forall concentrations of aqueous extracts and NSAID,the peak effects against PGE2 were at 0.5 to 1.0 h(Table 1). The ethanolic extract of Zingiber zerumbetwas devoid of any antiinflammatory effect with 25to 100 mg/kg concentrations (Group 4, 5 and 6).There was no significant difference at any time pointswhen compared to control (Data not shown).Antiinflammatory effects were observed against anacute (PGE2-induced paw edema) model of inflammationwhen rats were pre-treated with 50 and 100 mg/kg water extracts of Zingiber zerumbet. The extractswere devoid of any toxicity upto 500 mg/kg in rats. Theantiinflammatory effect of water extract was similar tothe reference NSAID mefenamic acid where the
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